Definition af selektiv serotonin genoptagelsesinhibitor

Selektiv serotonin genoptagelsesinhibitor: A Selektiv serotonin genoptagelsesinhibitor (SSRI) er et af de almindeligt ordinerede lægemidler til behandling af depression.

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SSRI'er påvirker de kemikalier, som nerver i hjernen bruger til at sende beskeder til hinanden. Disse kemiske budbringere kaldet neurotransmittere frigives af en nerve og optages af andre nerver. Neurotransmittere, der ikke optages af andre nerver, optages af de samme nerver, der frigav dem. Denne proces kaldes 'genoptagelse'. SSRI'er fungerer ved at hæmme genoptagelse af serotonin en handling, der tillader, at mere serotonin kan være tilgængeligt for at blive optaget af andre nerver.

De mest almindeligt foreskrevne SSRI'er fra 1999 var paroxetin (brandname paxil) fluoxetin (BrandName Prozac) og sertralin (Brandname Zoloft).

All three of these SSRIs appear equally efficacious according to a 1999 study. The rate of patients switching from one class of drugs to another did not differ among the drug classes studied and there was no significant difference in the proportion of patients who switched from an SSRI to another SSRI (or another type of antidepressant ) regardless of whether paroxetine (Paxil) fluoxetine (Prozac) or sertraline (Zoloft) was the initial therapy. These three SSRIs therefore are 'equivalent in their effectiveness' but they '...are not interchangeable because patients who discontinue one SSRI for lack of tolerability or response can generally be treated effectively with another.' (Reference: J Clin Psychiatry 1999;60:574-579.)

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